On the CCP4 Bulletin Board the following was presented:
Copper is a competitive inhibitor of my enzyme. I have crystals which have turned blue on soaking with copper salt. Assuming the worst scenario where there is only one copper bound to one enzyme (350 amino acids) would it be worth it to do a MAD experiment ? Thanks
There a some rules of thumb to check whether a MAD experiment is feasible or not :
However, these are not hard rules....